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qpatch automated patch-clamp platform  (Sophion Bioscience)

 
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    Structured Review

    Sophion Bioscience qpatch automated patch-clamp platform
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Qpatch Automated Patch Clamp Platform, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/qpatch+automated+patch+clamp+platform/qpatch+16+automated+electrophysiology+platform/pmc11808707-32-55-59
    Average 90 stars, based on 1 article reviews
    qpatch automated patch-clamp platform - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus"

    Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

    Journal: Pain

    doi: 10.1097/j.pain.0000000000003404

    Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Figure Legend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Techniques Used: Patch Clamp

    Related Articles

    other:

    Article Title: Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.
    Article Snippet: Introduction: High throughput in vitro profiling of the cardiac Nav1.5 peak sodium current (INa) is widely used in cardiac safety screening.. However, there is no standardized high throughput method to measure late INa.. This study assessed the pharmacological and biophysical properties of veratridine and ATX-II, as well as the channel mutation (Nav1.5-∆KPQ) on the late INa.



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    Image Search Results


    Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Journal: Pain

    Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

    doi: 10.1097/j.pain.0000000000003404

    Figure Lengend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

    Techniques: Patch Clamp